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デキストラン硫酸ナトリウム Colitisグレード

|大腸炎モデル動物作製用試薬|

 

ラット、マウスに飲水投与することで大腸炎を誘発させます。

デキストラン硫酸ナトリウム(DSS)は、ムコ多糖の一種で、腸粘膜上皮障害を起こします。粘膜バリア障害の結果、DSSは粘膜下層に達し抗原提示細胞に貪食され、活性化した抗原提示細胞がT細胞活性化を引き起こし、炎症性腸疾患と類似の症状を誘発すると考えられます。

 

MPバイオのColitis(大腸炎)グレードDSSは、3000以上の文献・出版物に記載され、大腸炎モデル作製用DSSのスタンダードとして世界中で使用されています。

 

使用例

使用例

参考文献

Bamba, S.; et al. The severity of dextran sodium sulfate-induced colitis can differ between dextran sodium sulfate preparations of the same molecular weight range. Digestive diseases and sciences. 2012, 57.2, 327–334.

 

Zheng, Z.; et al. Screening of an anti-inflammatory peptide from Hydrophis cyanocinctus and analysis of its activities and mechanism in DSS-induced acute colitis. Scientific reports. 2016, 6, 25672.

 

Chun-Sai-Er Wang; et al. VSL# 3 can prevent ulcerative colitis-associated carcinogenesis in mice. World journal of gastroenterology. 2018, 24.37, 4254.

 

Duan, S.; et al. Effect of vitexin on alleviating liver inflammation in a dextran sulfate sodium (DSS)-induced colitis model. Biomedicine & Pharmacotherapy. 2020, 121, 109683.

 

Xie, X.; et al. Rab32‐related antimicrobial pathway is involved in the progression of dextran sodium sulfate‐induced colitis. FEBS open bio. 2018, 8.10, 1658–1668

 

Boussenna, A.; et al. Dietary supplementation with a low dose of polyphenol-rich grape pomace extract prevents dextran sulfate sodium-induced colitis in rats. Journal of medicinal food. 2016, 19.8, 755–758.

 

Lv, J.; et al. Astragalus polysaccharides protect against dextran sulfate sodium-induced colitis by inhibiting NF-κВ activation. International journal of biological macromolecules. 2017, 98, 723–729.

 

Kim, S.-Y.; et al. Ro60 Inhibits Colonic Inflammation and Fibrosis in a Mouse Model of Dextran Sulfate Sodium-Induced Colitis. Immunology letters. 2018, 201, 45–51.

 

Boussenna, A.; et al. Polyphenol‐rich grape pomace extracts protect against dextran sulfate sodium‐induced colitis in rats. Journal of the Science of Food and Agriculture. 2016, 96.4, 1260–1268.

 

Crncec, I.; et al. Induction of colorectal cancer in mice and histomorphometric evaluation of tumors. Methods Mol. Biol. 2015, 1267, 145–64.

 

Gurav, A.; et al. Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions. Biochem. J. 2015, 469, 267–78.

 

Dai, X.; et al. MicroRNA-193a-3p Reduces Intestinal Inflammation in Response to Microbiota via Down-regulation of Colonic PepT1. J. Biol. Chem. 2015, 290, 16099–115.

 

 

参考文献

参考資料

https://media.mpbio.com/document/file/brochure/dest/l/s/0/3/2/LS032020-EN-DSS-Brochure.pdf