デキストラン硫酸ナトリウム Colitisグレード
｜大腸炎モデル動物作製用試薬｜
ラット、マウスに飲水投与することで大腸炎を誘発させます。
デキストラン硫酸ナトリウム（DSS）は、ムコ多糖の一種で、腸粘膜上皮障害を起こします。
粘膜バリア障害の結果、DSSは粘膜下層に達し抗原提示細胞に貪食され、活性化した抗原提示細胞がT細胞活性化を引き起こし、炎症性腸疾患と類似の症状を誘発すると考えられます。
MPバイオのColitis(大腸炎）グレードDSSは、8,000以上の文献・出版物に記載され、大腸炎モデル作製用DSSのスタンダードとして世界中で使用されています。
使用例
参考文献
Bamba, S.; et al. The severity of dextran sodium sulfate-induced colitis can differ between dextran sodium sulfate preparations of the same molecular weight range. Digestive diseases and sciences. 2012, 57.2, 327–334.
Zheng, Z.; et al. Screening of an anti-inflammatory peptide from Hydrophis cyanocinctus and analysis of its activities and mechanism in DSS-induced acute colitis. Scientific reports. 2016, 6, 25672.
Chun-Sai-Er Wang; et al. VSL# 3 can prevent ulcerative colitis-associated carcinogenesis in mice. World journal of gastroenterology. 2018, 24.37, 4254.
Duan, S.; et al. Effect of vitexin on alleviating liver inflammation in a dextran sulfate sodium (DSS)-induced colitis model. Biomedicine & Pharmacotherapy. 2020, 121, 109683.
Xie, X.; et al. Rab32‐related antimicrobial pathway is involved in the progression of dextran sodium sulfate‐induced colitis. FEBS open bio. 2018, 8.10, 1658–1668
Boussenna, A.; et al. Dietary supplementation with a low dose of polyphenol-rich grape pomace extract prevents dextran sulfate sodium-induced colitis in rats. Journal of medicinal food. 2016, 19.8, 755–758.
Lv, J.; et al. Astragalus polysaccharides protect against dextran sulfate sodium-induced colitis by inhibiting NF-κВ activation. International journal of biological macromolecules. 2017, 98, 723–729.
Kim, S.-Y.; et al. Ro60 Inhibits Colonic Inflammation and Fibrosis in a Mouse Model of Dextran Sulfate Sodium-Induced Colitis. Immunology letters. 2018, 201, 45–51.
Boussenna, A.; et al. Polyphenol‐rich grape pomace extracts protect against dextran sulfate sodium‐induced colitis in rats. Journal of the Science of Food and Agriculture. 2016, 96.4, 1260–1268.